Knoxville (TYS) to Tampa (TPA) flights
One airline flies nonstop from Knoxville (TYS) to Tampa (TPA): Southwest Airlines. The two airports are 547 miles (881 km) apart. There are also 16 ways to fly it with one stop, through Atlanta, Birmingham and Charlotte and more.
Airlines flying nonstop from TYS to TPA
- Southwest AirlinesNot in an allianceWho books it
TYS to TPA with one stop
16 connections, most direct first. 2-stop routings and flight times are in Routes with Pro.
- Via Atlanta (ATL)Delta Air Lines the whole way
- Via Birmingham (BHM)United Airlines, then Southwest Airlines
- Via Charlotte (CLT)American Airlines the whole way
- Via Nashville (BNA)Southwest Airlines the whole way
- Via Fort Lauderdale (FLL)Allegiant Air, then Southwest Airlines, JetBlue Airways and 1 more
- Via Miami (MIA)American Airlines the whole way
- Via Memphis (MEM)Allegiant Air, then Southwest Airlines and Breeze Airways
- Via Key West (EYW)Allegiant Air, then Breeze Airways
- Via New Orleans (MSY)Southwest Airlines the whole way
- Via Dulles (IAD)United Airlines the whole way
- Via Washington (DCA)American Airlines the whole way
- Via Baltimore (BWI)Southwest Airlines the whole way
- Via Detroit (DTW)Delta Air Lines the whole way
- Via Chicago (MDW)Allegiant Air, then Southwest Airlines
- Via Bentonville (XNA)Delta Air Lines, then Breeze Airways
TYS to TPA: common questions
Which airlines fly nonstop from TYS to TPA?
Southwest Airlines flies nonstop from Knoxville (TYS) to Tampa (TPA).
How far is Knoxville from Tampa by plane?
Knoxville (TYS) and Tampa (TPA) are 547 miles (881 km) apart along the great circle, the shortest path a flight can take. Connections add distance on top.
How many miles does TYS to TPA cost?
It depends on the program: each prices the route from its own chart or dynamically. The Award Flight Pricer compares 30+ programs for TYS to TPA with taxes and fees.
Where can I connect between Knoxville and Tampa?
The most direct connections are through Atlanta (ATL), Birmingham (BHM), Charlotte (CLT), Nashville (BNA) and Fort Lauderdale (FLL). On 10 of them the same airline flies both flights, for example Delta Air Lines through Atlanta.
More routes
Routes are scheduled nonstop flights. The route data is refreshed monthly; this list was last checked November 11, 2026. Seasonal routes and new launches can be missing or end early, so confirm with the airline before you book. Distances are great-circle, the shortest path between the two airports.