Tampa (TPA) to Knoxville (TYS) flights
One airline flies nonstop from Tampa (TPA) to Knoxville (TYS): Southwest Airlines. The two airports are 547 miles (881 km) apart. There are also 16 ways to fly it with one stop, through Atlanta, Birmingham and Charlotte and more.
Airlines flying nonstop from TPA to TYS
- Southwest AirlinesNot in an allianceWho books it
TPA to TYS with one stop
16 connections, most direct first. 2-stop routings and flight times are in Routes with Pro.
- Via Atlanta (ATL)Delta Air Lines the whole way
- Via Birmingham (BHM)Southwest Airlines, then United Airlines
- Via Charlotte (CLT)American Airlines the whole way
- Via Nashville (BNA)Southwest Airlines the whole way
- Via Fort Lauderdale (FLL)Southwest Airlines, JetBlue Airways and 1 more, then Allegiant Air
- Via Miami (MIA)American Airlines the whole way
- Via Memphis (MEM)Southwest Airlines and Breeze Airways, then Allegiant Air
- Via Key West (EYW)Breeze Airways, then Allegiant Air
- Via New Orleans (MSY)Southwest Airlines the whole way
- Via Dulles (IAD)United Airlines the whole way
- Via Washington (DCA)American Airlines the whole way
- Via Baltimore (BWI)Southwest Airlines the whole way
- Via Detroit (DTW)Delta Air Lines the whole way
- Via Chicago (MDW)Southwest Airlines, then Allegiant Air
- Via Bentonville (XNA)Breeze Airways, then Delta Air Lines
TPA to TYS: common questions
Which airlines fly nonstop from TPA to TYS?
Southwest Airlines flies nonstop from Tampa (TPA) to Knoxville (TYS).
How far is Tampa from Knoxville by plane?
Tampa (TPA) and Knoxville (TYS) are 547 miles (881 km) apart along the great circle, the shortest path a flight can take. Connections add distance on top.
How many miles does TPA to TYS cost?
It depends on the program: each prices the route from its own chart or dynamically. The Award Flight Pricer compares 30+ programs for TPA to TYS with taxes and fees.
Where can I connect between Tampa and Knoxville?
The most direct connections are through Atlanta (ATL), Birmingham (BHM), Charlotte (CLT), Nashville (BNA) and Fort Lauderdale (FLL). On 10 of them the same airline flies both flights, for example Delta Air Lines through Atlanta.
More routes
Routes are scheduled nonstop flights. The route data is refreshed monthly; this list was last checked November 11, 2026. Seasonal routes and new launches can be missing or end early, so confirm with the airline before you book. Distances are great-circle, the shortest path between the two airports.