Knoxville (TYS) to New Orleans (MSY) flights
2 airlines fly nonstop from Knoxville (TYS) to New Orleans (MSY): American Airlines and Southwest Airlines. The two airports are 542 miles (872 km) apart. American Airlines is in oneworld. There are also 20 ways to fly it with one stop, through Atlanta, Nashville and Charlotte and more.
Airlines flying nonstop from TYS to MSY
- American Airlinesoneworld · bookable with 9 programsWho books it
- Southwest AirlinesNot in an allianceWho books it
Book TYS to MSY with points
Loyalty programs that can book at least one of the nonstop airlines, from the Award Booking Guide.
- Alaska Atmos RewardsBooks American Airlines
- American AAdvantageBooks American Airlines
- British Airways ClubBooks American Airlines
- Cathay Pacific Asia MilesBooks American Airlines
- Finnair PlusBooks American Airlines
- Iberia ClubBooks American Airlines
- JAL Mileage BankBooks American Airlines
- Qantas Frequent FlyerBooks American Airlines
- Qatar Airways Privilege ClubBooks American Airlines
TYS to MSY with one stop
20 connections, most direct first. 2-stop routings and flight times are in Routes with Pro.
- Via Atlanta (ATL)Delta Air Lines the whole way
- Via Nashville (BNA)Southwest Airlines the whole way
- Via Charlotte (CLT)American Airlines the whole way
- Via Jacksonville (JAX)Allegiant Air, then Breeze Airways
- Via Tampa (TPA)Southwest Airlines the whole way
- Via Bentonville (XNA)Delta Air Lines, then Breeze Airways
- Via Houston (IAH)United Airlines the whole way
- Via Orlando (MCO)Southwest Airlines the whole way
- Via Houston (HOU)Allegiant Air, then Southwest Airlines
- Via Dallas (DAL)Southwest Airlines the whole way
- Via Dallas (DFW)American Airlines the whole way
- Via Chicago (MDW)Allegiant Air, then Southwest Airlines
- Via Chicago (ORD)American Airlines and United Airlines the whole way
- Via Austin (AUS)Southwest Airlines and Delta Air Lines the whole way+1
- Via Detroit (DTW)Delta Air Lines the whole way
TYS to MSY: common questions
Which airlines fly nonstop from TYS to MSY?
American Airlines (oneworld) and Southwest Airlines fly nonstop from Knoxville (TYS) to New Orleans (MSY).
How far is Knoxville from New Orleans by plane?
Knoxville (TYS) and New Orleans (MSY) are 542 miles (872 km) apart along the great circle, the shortest path a flight can take. Connections add distance on top.
Which points programs can book TYS to MSY award flights?
9 programs can book at least one of the nonstop airlines: Alaska Atmos Rewards, American AAdvantage, British Airways Club, Cathay Pacific Asia Miles, Finnair Plus, Iberia Club, JAL Mileage Bank, Qantas Frequent Flyer and 1 more. Which flights each can book depends on its partners, so check the airline before you transfer points.
How many miles does TYS to MSY cost?
It depends on the program: each prices the route from its own chart or dynamically. The Award Flight Pricer compares 30+ programs for TYS to MSY with taxes and fees.
Where can I connect between Knoxville and New Orleans?
The most direct connections are through Atlanta (ATL), Nashville (BNA), Charlotte (CLT), Jacksonville (JAX) and Tampa (TPA). On 15 of them the same airline flies both flights, for example Delta Air Lines through Atlanta.
More routes
Routes are scheduled nonstop flights. The route data is refreshed monthly; this list was last checked November 11, 2026. Seasonal routes and new launches can be missing or end early, so confirm with the airline before you book. Distances are great-circle, the shortest path between the two airports.