New Orleans (MSY) to Knoxville (TYS) flights
2 airlines fly nonstop from New Orleans (MSY) to Knoxville (TYS): American Airlines and Southwest Airlines. The two airports are 542 miles (872 km) apart. American Airlines is in oneworld. There are also 21 ways to fly it with one stop, through Atlanta, Nashville and Memphis and more.
Airlines flying nonstop from MSY to TYS
- American Airlinesoneworld · bookable with 9 programsWho books it
- Southwest AirlinesNot in an allianceWho books it
Book MSY to TYS with points
Loyalty programs that can book at least one of the nonstop airlines, from the Award Booking Guide.
- Alaska Atmos RewardsBooks American Airlines
- American AAdvantageBooks American Airlines
- British Airways ClubBooks American Airlines
- Cathay Pacific Asia MilesBooks American Airlines
- Finnair PlusBooks American Airlines
- Iberia ClubBooks American Airlines
- JAL Mileage BankBooks American Airlines
- Qantas Frequent FlyerBooks American Airlines
- Qatar Airways Privilege ClubBooks American Airlines
MSY to TYS with one stop
21 connections, most direct first. 2-stop routings and flight times are in Routes with Pro.
- Via Atlanta (ATL)Delta Air Lines the whole way
- Via Nashville (BNA)Southwest Airlines the whole way
- Via Memphis (MEM)American Airlines, then Allegiant Air
- Via Charlotte (CLT)American Airlines the whole way
- Via Jacksonville (JAX)Breeze Airways, then Allegiant Air
- Via Tampa (TPA)Southwest Airlines the whole way
- Via Bentonville (XNA)Breeze Airways, then Delta Air Lines
- Via Houston (IAH)United Airlines the whole way
- Via Orlando (MCO)Southwest Airlines the whole way
- Via Houston (HOU)Southwest Airlines, then Allegiant Air
- Via Dallas (DAL)Southwest Airlines the whole way
- Via Dallas (DFW)American Airlines the whole way
- Via Chicago (MDW)Southwest Airlines, then Allegiant Air
- Via Chicago (ORD)American Airlines and United Airlines the whole way
- Via Austin (AUS)Southwest Airlines and Delta Air Lines the whole way+1
MSY to TYS: common questions
Which airlines fly nonstop from MSY to TYS?
American Airlines (oneworld) and Southwest Airlines fly nonstop from New Orleans (MSY) to Knoxville (TYS).
How far is New Orleans from Knoxville by plane?
New Orleans (MSY) and Knoxville (TYS) are 542 miles (872 km) apart along the great circle, the shortest path a flight can take. Connections add distance on top.
Which points programs can book MSY to TYS award flights?
9 programs can book at least one of the nonstop airlines: Alaska Atmos Rewards, American AAdvantage, British Airways Club, Cathay Pacific Asia Miles, Finnair Plus, Iberia Club, JAL Mileage Bank, Qantas Frequent Flyer and 1 more. Which flights each can book depends on its partners, so check the airline before you transfer points.
How many miles does MSY to TYS cost?
It depends on the program: each prices the route from its own chart or dynamically. The Award Flight Pricer compares 30+ programs for MSY to TYS with taxes and fees.
Where can I connect between New Orleans and Knoxville?
The most direct connections are through Atlanta (ATL), Nashville (BNA), Memphis (MEM), Charlotte (CLT) and Jacksonville (JAX). On 15 of them the same airline flies both flights, for example Delta Air Lines through Atlanta.
More routes
Routes are scheduled nonstop flights. The route data is refreshed monthly; this list was last checked November 11, 2026. Seasonal routes and new launches can be missing or end early, so confirm with the airline before you book. Distances are great-circle, the shortest path between the two airports.