Knoxville (TYS) to Chicago (MDW) flights
One airline flies nonstop from Knoxville (TYS) to Chicago (MDW): Allegiant Air. The two airports are 460 miles (740 km) apart. There are also 14 ways to fly it with one stop, through Nashville, Detroit and Atlanta and more.
Airlines flying nonstop from TYS to MDW
- Allegiant AirNot in an alliance
TYS to MDW with one stop
14 connections, most direct first. 2-stop routings and flight times are in Routes with Pro.
- Via Nashville (BNA)Southwest Airlines the whole way
- Via Detroit (DTW)Delta Air Lines the whole way
- Via Atlanta (ATL)Delta Air Lines the whole way
- Via Charlotte (CLT)American Airlines, then Southwest Airlines
- Via Birmingham (BHM)United Airlines, then Southwest Airlines
- Via Memphis (MEM)Allegiant Air, then Southwest Airlines
- Via Washington (DCA)American Airlines and Delta Air Lines, then Southwest Airlines
- Via Baltimore (BWI)Southwest Airlines the whole way
- Via Minneapolis (MSP)Delta Air Lines the whole way
- Via Fort Walton Beach (VPS)Allegiant Air the whole way
- Via Philadelphia (PHL)American Airlines and Allegiant Air, then Southwest Airlines
- Via Jacksonville (JAX)Allegiant Air, then Southwest Airlines
- Via New Orleans (MSY)Southwest Airlines the whole way
- Via New York (LGA)Delta Air Lines and American Airlines, then Southwest Airlines
TYS to MDW: common questions
Which airlines fly nonstop from TYS to MDW?
Allegiant Air flies nonstop from Knoxville (TYS) to Chicago (MDW).
How far is Knoxville from Chicago by plane?
Knoxville (TYS) and Chicago (MDW) are 460 miles (740 km) apart along the great circle, the shortest path a flight can take. Connections add distance on top.
How many miles does TYS to MDW cost?
It depends on the program: each prices the route from its own chart or dynamically. The Award Flight Pricer compares 30+ programs for TYS to MDW with taxes and fees.
Where can I connect between Knoxville and Chicago?
The most direct connections are through Nashville (BNA), Detroit (DTW), Atlanta (ATL), Charlotte (CLT) and Birmingham (BHM). On 7 of them the same airline flies both flights, for example Southwest Airlines through Nashville.
More routes
Routes are scheduled nonstop flights. The route data is refreshed monthly; this list was last checked November 11, 2026. Seasonal routes and new launches can be missing or end early, so confirm with the airline before you book. Distances are great-circle, the shortest path between the two airports.