Chicago (MDW) to Knoxville (TYS) flights
One airline flies nonstop from Chicago (MDW) to Knoxville (TYS): Allegiant Air. The two airports are 460 miles (740 km) apart. There are also 14 ways to fly it with one stop, through Nashville, Detroit and Atlanta and more.
Airlines flying nonstop from MDW to TYS
- Allegiant AirNot in an alliance
MDW to TYS with one stop
14 connections, most direct first. 2-stop routings and flight times are in Routes with Pro.
- Via Nashville (BNA)Southwest Airlines the whole way
- Via Detroit (DTW)Delta Air Lines the whole way
- Via Atlanta (ATL)Delta Air Lines the whole way
- Via Charlotte (CLT)Southwest Airlines, then American Airlines
- Via Birmingham (BHM)Southwest Airlines, then United Airlines
- Via Memphis (MEM)Southwest Airlines, then Allegiant Air
- Via Washington (DCA)Southwest Airlines, then American Airlines and Delta Air Lines
- Via Baltimore (BWI)Southwest Airlines the whole way
- Via Minneapolis (MSP)Delta Air Lines the whole way
- Via Fort Walton Beach (VPS)Allegiant Air the whole way
- Via Philadelphia (PHL)Southwest Airlines, then American Airlines and Allegiant Air
- Via Jacksonville (JAX)Southwest Airlines, then Allegiant Air
- Via New Orleans (MSY)Southwest Airlines the whole way
- Via New York (LGA)Southwest Airlines, then Delta Air Lines and American Airlines
MDW to TYS: common questions
Which airlines fly nonstop from MDW to TYS?
Allegiant Air flies nonstop from Chicago (MDW) to Knoxville (TYS).
How far is Chicago from Knoxville by plane?
Chicago (MDW) and Knoxville (TYS) are 460 miles (740 km) apart along the great circle, the shortest path a flight can take. Connections add distance on top.
How many miles does MDW to TYS cost?
It depends on the program: each prices the route from its own chart or dynamically. The Award Flight Pricer compares 30+ programs for MDW to TYS with taxes and fees.
Where can I connect between Chicago and Knoxville?
The most direct connections are through Nashville (BNA), Detroit (DTW), Atlanta (ATL), Charlotte (CLT) and Birmingham (BHM). On 7 of them the same airline flies both flights, for example Southwest Airlines through Nashville.
More routes
Routes are scheduled nonstop flights. The route data is refreshed monthly; this list was last checked November 11, 2026. Seasonal routes and new launches can be missing or end early, so confirm with the airline before you book. Distances are great-circle, the shortest path between the two airports.