Colombia to Chile · 2,751 miles (4,427 km)

Medellin (MDE) to Santiago (SCL) flights

One airline flies nonstop from Medellin (MDE) to Santiago (SCL): JetSMART. The two airports are 2,751 miles (4,427 km) apart. There are also 10 ways to fly it with one stop, through Cali, Bogota and Lima and more.

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Airlines flying nonstop from MDE to SCL

JetSMARTNot in an alliance

MDE to SCL with one stop

10 connections, most direct first. 2-stop routings and flight times are in Routes with Pro.

Via Cali (CLO)JetSMART the whole way
Via Bogota (BOG)AVIANCA, LATAM Airlines and 1 more the whole way
P5
+1
Via Lima (LIM)LATAM Airlines and JetSMART the whole way
Via Quito (UIO)AVIANCA, then LATAM Airlines
Via Guayaquil (GYE)AVIANCA, then LATAM Airlines
Via Panama City (PTY)Copa Airlines the whole way
Via Cartagena (CTG)AVIANCA the whole way
P5
+1
Via Buenos Aires (EZE)AVIANCA and JetSMART, then Sky Airline, KLM and 1 more
Via Punta Cana (PUJ)Arajet the whole way
P5
+1
Via Cancun (CUN)AVIANCA and Wingo, then LATAM Airlines
P5

MDE to SCL: common questions

Which airlines fly nonstop from MDE to SCL?

JetSMART flies nonstop from Medellin (MDE) to Santiago (SCL).

How far is Medellin from Santiago by plane?

Medellin (MDE) and Santiago (SCL) are 2,751 miles (4,427 km) apart along the great circle, the shortest path a flight can take. Connections add distance on top.

How many miles does MDE to SCL cost?

It depends on the program: each prices the route from its own chart or dynamically. The Award Flight Pricer compares 30+ programs for MDE to SCL with taxes and fees.

Where can I connect between Medellin and Santiago?

The most direct connections are through Cali (CLO), Bogota (BOG), Lima (LIM), Quito (UIO) and Guayaquil (GYE). On 6 of them the same airline flies both flights, for example JetSMART through Cali.

More routes

SCL to MDE Every nonstop from MDE Every nonstop from SCL

MDE to Madrid MAD MDE to Miami MIA MDE to Houston IAH MDE to New York JFK MDE to Orlando MCO MDE to Fort Lauderdale FLL MDE to Cancun CUN MDE to Mexico City MEX MDE to Bogota BOG MDE to Panama City PTY MDE to Punta Cana PUJ MDE to Guadalajara GDL

Routes are scheduled nonstop flights. The route data is refreshed monthly; this list was last checked November 11, 2026. Seasonal routes and new launches can be missing or end early, so confirm with the airline before you book. Distances are great-circle, the shortest path between the two airports.