Santiago (SCL) to Medellin (MDE) flights
One airline flies nonstop from Santiago (SCL) to Medellin (MDE): JetSMART. The two airports are 2,751 miles (4,427 km) apart. There are also 10 ways to fly it with one stop, through Cali, Bogota and Lima and more.
Airlines flying nonstop from SCL to MDE
- JetSMARTNot in an alliance

SCL to MDE with one stop
10 connections, most direct first. 2-stop routings and flight times are in Routes with Pro.
- Via Cali (CLO)JetSMART the whole way




- Via Bogota (BOG)AVIANCA, LATAM Airlines and 1 more the whole way




P5+1 - Via Lima (LIM)JetSMART and LATAM Airlines the whole way





- Via Quito (UIO)LATAM Airlines, then AVIANCA


- Via Guayaquil (GYE)LATAM Airlines, then AVIANCA


- Via Panama City (PTY)Copa Airlines the whole way


- Via Cartagena (CTG)AVIANCA the whole way

P5+1
- Via Buenos Aires (EZE)Sky Airline, KLM and 1 more, then AVIANCA and JetSMART





- Via Punta Cana (PUJ)Arajet the whole way



P5+1
- Via Cancun (CUN)LATAM Airlines, then AVIANCA and Wingo

P5
SCL to MDE: common questions
Which airlines fly nonstop from SCL to MDE?
JetSMART flies nonstop from Santiago (SCL) to Medellin (MDE).
How far is Santiago from Medellin by plane?
Santiago (SCL) and Medellin (MDE) are 2,751 miles (4,427 km) apart along the great circle, the shortest path a flight can take. Connections add distance on top.
How many miles does SCL to MDE cost?
It depends on the program: each prices the route from its own chart or dynamically. The Award Flight Pricer compares 30+ programs for SCL to MDE with taxes and fees.
Where can I connect between Santiago and Medellin?
The most direct connections are through Cali (CLO), Bogota (BOG), Lima (LIM), Quito (UIO) and Guayaquil (GYE). On 6 of them the same airline flies both flights, for example JetSMART through Cali.
More routes
Routes are scheduled nonstop flights. The route data is refreshed monthly; this list was last checked November 11, 2026. Seasonal routes and new launches can be missing or end early, so confirm with the airline before you book. Distances are great-circle, the shortest path between the two airports.