Mexico City (MEX) to Santiago (SCL) flights
2 airlines fly nonstop from Mexico City (MEX) to Santiago (SCL): Aeromexico and LATAM Airlines. The two airports are 4,099 miles (6,597 km) apart. Aeromexico is in SkyTeam. There are also 19 ways to fly it with one stop, through Lima, Quito and Cali and more.
Airlines flying nonstop from MEX to SCL
- AeromexicoSkyTeam · bookable with 8 programsWho books it
- LATAM AirlinesNot in an alliance · bookable with 3 programsWho books it
Book MEX to SCL with points
Loyalty programs that can book at least one of the nonstop airlines, from the Award Booking Guide.
- Delta SkyMilesBooks Aeromexico, LATAM Airlines
- Virgin Atlantic Flying ClubBooks Aeromexico, LATAM Airlines
- Aeromexico RewardsBooks Aeromexico
- Air France-KLM Flying BlueBooks Aeromexico
- Alaska Atmos RewardsBooks LATAM Airlines
- China Eastern Eastern MilesBooks Aeromexico
- Garuda Indonesia GarudaMilesBooks Aeromexico
- Korean Air SKYPASSBooks Aeromexico
- SAS EuroBonusBooks Aeromexico
MEX to SCL with one stop
19 connections, most direct first. 2-stop routings and flight times are in Routes with Pro.
- Via Lima (LIM)LATAM Airlines the whole way
- Via Quito (UIO)Aeromexico, then LATAM Airlines
- Via Cali (CLO)Aeromexico, then JetSMART
- Via Panama City (PTY)Copa Airlines the whole way
- Via Medellin (MDE)Aeromexico and AVIANCA, then JetSMART
- Via Bogota (BOG)AVIANCA the whole way
- Via Cancun (CUN)Aeromexico, VivaAerobus and 2 more, then LATAM Airlines
+1 - Via Cartagena (CTG)Aeromexico, then AVIANCA
- Via Buenos Aires (EZE)Aeromexico, then Sky Airline, KLM and 1 more
- Via Miami (MIA)American Airlines the whole way
- Via Houston (IAH)United Airlines the whole way
+1 - Via Punta Cana (PUJ)Aeromexico, then LATAM Airlines, Arajet and 1 more
- Via Dallas (DFW)American Airlines the whole way
- Via Atlanta (ATL)Delta Air Lines the whole way
- Via Sao Paulo (GRU)LATAM Airlines the whole way+1
MEX to SCL: common questions
Which airlines fly nonstop from MEX to SCL?
Aeromexico (SkyTeam) and LATAM Airlines fly nonstop from Mexico City (MEX) to Santiago (SCL).
How far is Mexico City from Santiago by plane?
Mexico City (MEX) and Santiago (SCL) are 4,099 miles (6,597 km) apart along the great circle, the shortest path a flight can take. Connections add distance on top.
Which points programs can book MEX to SCL award flights?
9 programs can book at least one of the nonstop airlines: Delta SkyMiles, Virgin Atlantic Flying Club, Aeromexico Rewards, Air France-KLM Flying Blue, Alaska Atmos Rewards, China Eastern Eastern Miles, Garuda Indonesia GarudaMiles, Korean Air SKYPASS and 1 more. Which flights each can book depends on its partners, so check the airline before you transfer points.
How many miles does MEX to SCL cost?
It depends on the program: each prices the route from its own chart or dynamically. The Award Flight Pricer compares 30+ programs for MEX to SCL with taxes and fees.
Where can I connect between Mexico City and Santiago?
The most direct connections are through Lima (LIM), Quito (UIO), Cali (CLO), Panama City (PTY) and Medellin (MDE). On 10 of them the same airline flies both flights, for example LATAM Airlines through Lima.
More routes
Routes are scheduled nonstop flights. The route data is refreshed monthly; this list was last checked November 11, 2026. Seasonal routes and new launches can be missing or end early, so confirm with the airline before you book. Distances are great-circle, the shortest path between the two airports.