Detroit (DTW) to Saint Louis (STL) flights
2 airlines fly nonstop from Detroit (DTW) to Saint Louis (STL): Delta Air Lines and Southwest Airlines. The two airports are 439 miles (707 km) apart. Delta Air Lines is in SkyTeam. There are also 21 ways to fly it with one stop, through Chicago, Chicago and Milwaukee and more.
Airlines flying nonstop from DTW to STL
- Delta Air LinesSkyTeam · bookable with 8 programsWho books it
- Southwest AirlinesNot in an allianceWho books it
Book DTW to STL with points
Loyalty programs that can book at least one of the nonstop airlines, from the Award Booking Guide.
- Aeromexico RewardsBooks Delta Air Lines
- Air France-KLM Flying BlueBooks Delta Air Lines
- China Eastern Eastern MilesBooks Delta Air Lines
- Delta SkyMilesBooks Delta Air Lines
- Garuda Indonesia GarudaMilesBooks Delta Air Lines
- Korean Air SKYPASSBooks Delta Air Lines
- SAS EuroBonusBooks Delta Air Lines
- Virgin Atlantic Flying ClubBooks Delta Air Lines
DTW to STL with one stop
21 connections, most direct first. 2-stop routings and flight times are in Routes with Pro.
- Via Chicago (MDW)Southwest Airlines the whole way
- Via Chicago (ORD)American Airlines and United Airlines the whole way
- Via Milwaukee (MKE)Delta Air Lines, then Southwest Airlines
- Via Columbus (CMH)Delta Air Lines, then Southwest Airlines
- Via Cleveland (CLE)Delta Air Lines, then Southwest Airlines
- Via Nashville (BNA)Southwest Airlines the whole way
- Via Pittsburgh (PIT)Delta Air Lines, then Southwest Airlines
- Via Kansas City (MCI)Delta Air Lines, then Southwest Airlines
- Via Toronto (YYZ)Air Canada the whole way
- Via Minneapolis (MSP)Delta Air Lines the whole way
- Via Omaha (OMA)Delta Air Lines, then Southwest Airlines
- Via Charlotte (CLT)American Airlines the whole way
- Via Atlanta (ATL)Delta Air Lines and Frontier Airlines the whole way
- Via Dulles (IAD)United Airlines the whole way
- Via Washington (DCA)American Airlines the whole way
DTW to STL: common questions
Which airlines fly nonstop from DTW to STL?
Delta Air Lines (SkyTeam) and Southwest Airlines fly nonstop from Detroit (DTW) to Saint Louis (STL).
How far is Detroit from Saint Louis by plane?
Detroit (DTW) and Saint Louis (STL) are 439 miles (707 km) apart along the great circle, the shortest path a flight can take. Connections add distance on top.
Which points programs can book DTW to STL award flights?
8 programs can book at least one of the nonstop airlines: Aeromexico Rewards, Air France-KLM Flying Blue, China Eastern Eastern Miles, Delta SkyMiles, Garuda Indonesia GarudaMiles, Korean Air SKYPASS, SAS EuroBonus and Virgin Atlantic Flying Club. Which flights each can book depends on its partners, so check the airline before you transfer points.
How many miles does DTW to STL cost?
It depends on the program: each prices the route from its own chart or dynamically. The Award Flight Pricer compares 30+ programs for DTW to STL with taxes and fees.
Where can I connect between Detroit and Saint Louis?
The most direct connections are through Chicago (MDW), Chicago (ORD), Milwaukee (MKE), Columbus (CMH) and Cleveland (CLE). On 12 of them the same airline flies both flights, for example Southwest Airlines through Chicago.
More routes
Routes are scheduled nonstop flights. The route data is refreshed monthly; this list was last checked November 11, 2026. Seasonal routes and new launches can be missing or end early, so confirm with the airline before you book. Distances are great-circle, the shortest path between the two airports.